Mouse IL-27 p28/IL-30 DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse IL-27 p28/IL-30 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Il27

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse IL-27 p28/IL-30 DuoSet ELISA, 15 Plate

• IL27 p28
• IL-27 p28
• IL27;IL-27;IL27A;IL-27A;IL27p28;IL-27p28;IL30;p28
• IL-30

Background

IL-27 is a heterodimeric cytokine that is composed of EBI3 (which is related to the p40 subunit of IL-12 and IL-23) and p28 (which is related to the p35 chain of IL-12). IL-27 is expressed by monocytes, endothelial cells, and dendritic cells, and it signals through a receptor complex composed of IL-27 R alpha/WSX-1/TCCR and gp130. IL-27 induces IL-12 receptor expression on naïve CD4+ T cells, sensitizing them to subsequent IL-12 induced Th1 development. It also functions as an anti-inflammatory cytokine by limiting T and NKT cell activity.

Publications for IL-27 p28/IL-30 (DY1834)(10)

Publications using DY1834

• AM Kelly, JM Leech, SL Doyle, RM McLoughlin Staphylococcus aureus-induced immunosuppression mediated by IL-10 and IL-27 facilitates nasal colonisation PloS Pathogens, 2022-07-01;18(7):e1010647. 2022-07-01 [PMID: 35776778] (Mouse)
• A Patidar, S Selvaraj, M Chakravart, I Guha, A Bhuniya, S Bera, S Dhar, K Roy, R Baral, D Chattopadh, C Pal, B Saha TLR induced IL-27 plays host-protective role against B16BL6 melanoma in C57BL/6 mice Cytokine, 2022-04-15;154(0):155871. 2022-04-15 [PMID: 35436657] (Mouse)
• HW Chen, CI Lin, YH Chuang Interleukin-30 Suppresses Not Only CD4+ T Cells but Also Regulatory T Cells in Murine Primary Biliary Cholangitis Biomedicines, 2021-08-17;9(8):. 2021-08-17 [PMID: 34440235] (Mouse)
• P Clua, M Tomokiyo, F Raya Tonet, MA Islam, V García Cas, G Marcial, S Salva, S Alvarez, H Takahashi, S Kurata, H Kitazawa, J Villena The Role of Alveolar Macrophages in the Improved Protection against Respiratory Syncytial Virus and Pneumococcal Superinfection Induced by the Peptidoglycan of Lactobacillus rhamnosus CRL1505 Cells, 2020-07-09;9(7):. 2020-07-09 [PMID: 32660087] (Mouse)
• Gesine Hansen IL-27 Is Essential for Suppression of Experimental Allergic Asthma by the TLR7/8 Agonist R848 (Resiquimod) J. Immunol., 2016-10-31;0(0):. 2016-10-31 [PMID: 27799314] (Mouse)
• Full Spectrum of LPS Activation in Alveolar Macrophages of Healthy Volunteers by Whole Transcriptomic Profiling PLoS ONE, 2016-07-19;11(7):e0159329. 2016-07-19 [PMID: 27434537] (Mouse)
• Gustavo F S Quirino Interleukin-27 Mediates Susceptibility to Visceral Leishmaniasis by Suppressing the IL-17-Neutrophil Response Infect Immun, 2016-07-21;0(0):. 2016-07-21 [PMID: 27245409] (Mouse)
• Andrographolide Restores Steroid Sensitivity To Block Lipopolysaccharide/IFN-?-Induced IL-27 and Airway Hyperresponsiveness in Mice J Immunol, 2016-05-02;196(11):4706-12. 2016-05-02 [PMID: 27183596] (Mouse)
• Kanagavelu S, Flores C, Termini J, Riveron R, Romero L, Chung K, Ruiz J, Hyun J, Yuan X, Dagvadorj J, Fukata M TIR-domain-containing adapter-inducing interferon-beta (TRIF) regulates Th17-mediated intestinal immunopathology in colitis. Mucosal Immunol, 2014-07-30;8(2):296-306. 2014-07-30 [PMID: 25073675] (Mouse)
• Sweeney CM, Lonergan R, Basdeo SA, Kinsella K, Dungan LS, Higgins SC, Kelly PJ, Costelloe L, Tubridy N, Mills KH, Fletcher JM IL-27 mediates the response to IFN-beta therapy in multiple sclerosis patients by inhibiting Th17 cells. Brain Behav. Immun., 2011-03-21;0(0):. 2011-03-21 [PMID: 21420486] (Mouse)

Bioinformatics

• Gene Symbol: Il27