Lactate Dehydrogenase A Inhibitor Screening Assay Kit (Colorimetric)

Lactate Dehydrogenase A Inhibitor Screening Colorimetric Assay Kit [NBP2-59751]

Product Discontinued

Lactate Dehydrogenase A Inhibitor Screening Assay Kit (Colorimetric) Summary

• Description: LDHA catalyzes the conversion of lactate to an intermediate that interacts with a probe to develop a color that can be measured at OD 450 nm. In the presence of a LDHA specific inhibitor, the reaction is impeded. A LDHA Inhibitor Control is included to compare the efficacy of the sample inhibitors. The assay is high-throughput adaptable and can be completed in less than 1 hr. This kit is useful for screening potential inhibitors of lactate dehydrogenase A.
  
  
  This product is manufactured by Abcam and distributed by Novus Biologicals. (Abcam Catalog Number: ab283393)
• Kit Type: Assay Kit (Colorimetric)

Packaging, Storage & Formulations

• Storage: Store at -20C in the dark. Avoid freeze-thaw cycles.

Background

The human oxidoreductase Lactate Dehydrogenase A (LDHA) (EC:1.1.1.27) is a key enzyme in lactic acid metabolism. It interconverts pyruvate and NADH to lactate and NAD+ respectively. In mammals, LDHA exists as a tetramer and is primarily found in skeletal muscle tissues. LDHA is a common marker to screen for tissue damage and is also known to promote tumor proliferation in breast, lung, and pancreatic cancer patients.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Kits are guaranteed for 6 months from date of receipt.