Japanese Encephalitis virus NS1 Antibody (995047) [Alexa Fluor® 350]

• Applications: ELISA
• Clone: 995047
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 350

Japanese Encephalitis virus NS1 Antibody (995047) [Alexa Fluor® 350] Summary

• Immunogen: Human embryonic kidney cell, HEK293-derived viral Japanese Encephalitis virus NS1 protein
  Thr798-Ala1146
  Accession # P32886
• Specificity: Detects viral Japanese Encephalitis virus NS1 protein in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

Japanese encephalitis virus (JEV) non-structural protein 1 (NS1) is produced by the Japanese encephalitis virus (JEV), a mosquito-borne flavivirus that is the leading cause of virus-induced encephalitis globally (1). Flavivirus NS1 is a multifunctional virulence factor. The glycosylated NS1 exists as a membrane-associated dimer after translocation into the endoplasmic reticulum lumen, where it is essential for viral genome replication (2). The secreted hexamer NS1 is involved in immune evasion and pathogenesis; it is identified as a potential diagnostic marker for early detection of the virus infections (2). Mature viral JEV NS1 contains 352 amino acids and shares high structural similarity to other flavivirus NS1 proteins, such as DENV and ZIKV.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.