Influenza A Virus M2 Antibody (14C2)


Immunocytochemistry/ Immunofluorescence: Influenza A Virus M2 Antibody (14C2) [NB100-2073] - Analysis of MDCK cells

Product Details

Reactivity Hu, V-Vi, XpSpecies Glossary
Applications WB, Flow, ICC/IF, IP, B/N
1 mg/ml

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Influenza A Virus M2 Antibody (14C2) Summary

M2 protein from A/WSN/33-infected CV1 cell lysate.
IgG1 Kappa
Protein A purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Western Blot 1 ug/ml
  • Flow Cytometry 1:10 - 1:1000
  • Immunocytochemistry/Immunofluorescence 1:10-1:500
  • Immunoprecipitation 10 ug/ml
  • Block/Neutralize
Application Notes
Blocking usage reported in literature (PMID: 7571410). WB: Detects an approx. 15 kDa protein representing the M2 protein. It has demonstrated the ability to restrict the replication of some strains of influenza A virus by binding to the extracellular N-Terminal domain. May be useful in IHC.
Read Publications using
NB100-2073 in the following applications:

  • 2 publications
  • WB
    3 publications

Reactivity Notes

Human reactivity reported in scientific literature (PMID: 23049700).

Packaging, Storage & Formulations

Store at -20C. Avoid freeze-thaw cycles.
PBS with 1 mg/ml BSA
0.05% Sodium Azide
1 mg/ml
Protein A purified


Influenza A virus is an enveloped virus encoding 10 polypeptides. RNA segment 7 encodes for two proteins: M1 (matrix 1) and M2 (matrix 2). M1 protein is encoded by an mRNA that is colinear, while M2 protein is synthesized from spliced mRNA. M2 protein is a transmembrane protein composed of three Domains: 1) 24 residues representing the N-terminal region, 2) 19 hydro-phobic residues that serve as a membrane anchor, and 3) 54 residues near the C-terminal in the cytoplasmic domain. The M2 protein has been found to play a role in Influenza replication and assembly of virion particles. Further experimentation has demonstrated that this protein is an acid-activated ion channel for virus replication.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Influenza A Virus M2 Antibody (NB100-2073)(7)

We have publications tested in 3 confirmed species: Human, Virus, Xenopus.

We have publications tested in 2 applications: FLOW, WB.

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Showing Publications 1 - 7 of 7.
Publications using NB100-2073 Applications Species
Schmid ET, Pang IK, Carrera Silva EA et al. AXL receptor tyrosine kinase is required for T cell priming and antiviral immunity. Elife 2016 Jun 28 [PMID: 27350258] (FLOW) FLOW
Londino JD, Lazrak A, Noah JW et al. Influenza virus M2 targets cystic fibrosis transmembrane conductance regulator for lysosomal degradation during viral infection. FASEB J. 2015 Mar 20 [PMID: 25795456] (WB, Human) WB Human
Pang IK, Pillai PS, Iwasaki A et al. Efficient influenza A virus replication in the respiratory tract requires signals from TLR7 and RIG-I. Proc Natl Acad Sci U S A 2013 Aug 5 [PMID: 23918369] (FLOW, Virus) FLOW Virus
Londino JD, Lazrak A, Jurkuvenaite A et al. Influenza Matrix Protein 2 Alters CFTR Expression and Function through its Ion Channel Activity Am J Physiol Lung Cell Mol Physiol 2013 Mar 1 [PMID: 23457187] (WB, Xenopus, Human) WB Xenopus, Human
Lin SC, Lin YF, Chong P, Wu SC. Broader Neutralizing Antibodies against H5N1 Viruses Using Prime-Boost Immunization of Hyperglycosylated Hemagglutinin DNA and Virus-Like Particles PLoS One 2012 [PMID: 22720032] (WB) WB
Wei H-J, Chang W, Lin S-C et al. Fabrication of influenza virus-like particles using M2 fusion proteins for imaging single viruses and designing vaccines. Vaccine. 2011 Jun 7. [PMID: 21651946]
Pan YS, Wei HJ, Chang CC et al. Construction and characterization of insect cell-derived influenza VLP: cell binding, fusion, and EGFP incorporation. J Biomed Biotechnol 2010 [PMID: 21197092]

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for Influenza A Virus M2 Antibody (NB100-2073). (Showing 1 - 1 of 1 FAQs).

  1. Could you cite this antibody's purity % as well as the means by which purity was determined?
    • This particular antibody was protein G purified from ascites. We unfortunately do not measure the purity of our antibodies, but it is expected to be above 95%.

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