Resistance to G418 is conferred by the neo gene from transposon Tn5
encoding an aminoglycoside 3'-phosphotransferase, APH 3' II 3. This
protein inactivates G418 by covalently modifying its amino or hydroxyl
functions therefore inhibiting the antibiotic-ribosome interaction.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration is not relevant for this product. Please see the protocols for proper use of this product.
G418 is used for the selection and maintenance of eukaryotic cells
expressing the neo gene1. G418 is an aminoglycoside antibiotic similar
in structure to gentamycin B1, produced by Micromonospora
rhodorangea. Unlike gentamycin, G418 blocks polypeptide synthesis
in eukaryotic cells by binding irreversibly to 80S ribosomes and
therefore disrupting their proofreading capability.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Inhibitors are guaranteed
for 1 year from date of receipt.
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