CD17 Antibody (MEM-74)

Product Discontinued

CD17 Antibody (MEM-74) Summary

• Immunogen: Pre-B cell line NALM-6.
• Localization: Cell Membrane and Cytoplasmic
• Specificity: The recognizes the membrane lipid moiety lactosylceramide (CDw17).
• Isotype: IgM
• Clonality: Monoclonal
• Host: Mouse
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
• Application Notes: FACS: Use at an assay dependent dilution. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user.

Reactivity Notes

Cross-reacts with Human.Not yet tested in other species.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: 0.09% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for CD17 Antibody (MEM-74)

• and amp;#223;-D-galactosyl-(1-4)- and amp;#223;-D-glucosyl-(1-1 and #039;)-ceramide
• Lactosylceramide

Background

CD17, lactosylceramide, is an ubiquitous glycosphingolipid with uncharged disaccharide headgroup, highly enriched in lipid raft-derived structures. Besides playing a pivotal role in the biosynthesis of complex glycosphingilipids, lactosylceramide is involved in cell-cell and cell-matrix interactions and in signaling events linked to cell differentiation, development, apoptosis and oncogenesis. Lactosylceramide regulates integrin functions and production of nitric oxide. Its expression defines successive stages in the maturation of myeloid cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.