CD17 Antibody (MEM-68) [PE/Cy5.5]

Product Discontinued

CD17 Antibody (MEM-68) [PE/Cy5.5] Summary

• Immunogen: Pre-B cell line NALM-6
• Specificity: The mouse monoclonal antibody MEM-68 recognizes CD17, a membrane lipid moiety lactosylceramide expressed on granulocytes, monocytes and platelets.
• Isotype: IgM
• Clonality: Monoclonal
• Host: Mouse
• Purity: Ion exchange chromatography

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
• Application Notes: Optimal dilution of this antibody should be experimentally determined. For optimal results using our Tandem dyes, please avoid prolonged exposure to light or extreme temperature fluctuations. These can lead to irreversible degradation or decoupling. When staining intracellular targets, specific attention to the fixation and permeabilization steps in your flow protocol may be required. Please contact our technical support team at technical@novusbio.com if you have any questions.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark. Do not freeze.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Ion exchange chromatography

Notes

Cy is a registered trademark of Global Life Sciences Solutions Germany GmbH.

Alternate Names for CD17 Antibody (MEM-68) [PE/Cy5.5]

• and amp;#223;-D-galactosyl-(1-4)- and amp;#223;-D-glucosyl-(1-1 and #039;)-ceramide
• Lactosylceramide

Background

CD17, lactosylceramide, is an ubiquitous glycosphingolipid with uncharged disaccharide headgroup, highly enriched in lipid raft-derived structures. Besides playing a pivotal role in the biosynthesis of complex glycosphingilipids, lactosylceramide is involved in cell-cell and cell-matrix interactions and in signaling events linked to cell differentiation, development, apoptosis and oncogenesis. Lactosylceramide regulates integrin functions and production of nitric oxide. Its expression defines successive stages in the maturation of myeloid cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.