CD17 Antibody (MEM-68) [Janelia Fluor® 549]

Product Discontinued

CD17 Antibody (MEM-68) [Janelia Fluor® 549] Summary

• Immunogen: Pre-B cell line NALM-6
• Specificity: The mouse monoclonal antibody MEM-68 recognizes CD17, a membrane lipid moiety lactosylceramide expressed on granulocytes, monocytes and platelets.
• Isotype: IgM
• Clonality: Monoclonal
• Host: Mouse
• Purity: Ion exchange chromatography

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Ion exchange chromatography

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for CD17 Antibody (MEM-68) [Janelia Fluor® 549]

• and amp;#223;-D-galactosyl-(1-4)- and amp;#223;-D-glucosyl-(1-1 and #039;)-ceramide
• Lactosylceramide

Background

CD17, lactosylceramide, is an ubiquitous glycosphingolipid with uncharged disaccharide headgroup, highly enriched in lipid raft-derived structures. Besides playing a pivotal role in the biosynthesis of complex glycosphingilipids, lactosylceramide is involved in cell-cell and cell-matrix interactions and in signaling events linked to cell differentiation, development, apoptosis and oncogenesis. Lactosylceramide regulates integrin functions and production of nitric oxide. Its expression defines successive stages in the maturation of myeloid cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.