Bovine spongiform encephalopathy Antibody Pack

Product Discontinued

Bovine spongiform encephalopathy Antibody Pack Summary

• Immunogen: The following antibodies are included in this BSE antibody bundle: Format: Purified Rabbit IgG polyclonal antibody; Application: western blot; Immunogen: amino acids 142-148
  Format: Purified Rabbit IgG polyclonal antibody; Application: western blot; Immunogen: amino acids 162-170
  Format: Purified Rabbit IgG polyclonal antibody; Application: western blot; Immunogen: amino acids 217-229
  Format:Rabbit sera; Application: ELISA; Immunogen: amino acids 79-97
• Host: Sheep

Applications/Dilutions

• Dilutions:
  • Peptide ELISA 1:100-1:2000
  • Western Blot 1:100-1:2000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Alternate Names for Bovine spongiform encephalopathy Antibody Pack

• BSE Bovine spongiform encephalopathy [ Bos taurus (cattle) ]
• BSE Bovine spongiform encephalopathy Bos taurus cattle
• BSE Bovine spongiform encephalopathy
• BSE

Background

SE, also known as prion protein, is a membrane glycosylphosphatidylinositol-anchored glycoprotein belonging to the prion family of proteins and is responsible for several transmissible neurodegenerative spongiform encephalopathies. Though the exact function of BSE is not clear, reports suggest that it has a tendency to aggregate forming polymers known as rods and might act as a signaling neurotransmitter. BSE acts as a potent anti-apoptotic protein against BAX-mediated cell-death. Expression is higher in the brain of humans and animals infected with several degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), and transmissible mink encephalopathy (TME). Aberration in this protein is also associated with fatal familial insomnia and Huntington disease-like 1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Antibody Packs are guaranteed for 1 year from date of receipt.