Biotin-geldanamycin

Product Image: Biotin-geldanamycin [NB110-81560] - Chemical structure of Geldanamycin- Biotin (NB110-81560), a Biotin-geldanamycin. Molecular Formula: C55H87N7O17S. Molecular Weight: 560.6 g/mol.

• Applications: NULL

Biotin-geldanamycin Summary

• Description: Hsp90 inhibitor. MW 560.6.
• Specificity: Biotin- geldanamycin Compound

Applications/Dilutions

• Dilutions:
  • Product Image
• Application Notes: Synthetic Geldanamycin-Biotin 98% pure. Purple solid. Soluble in DMSO.

Reactivity Notes

Not species specific.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.

Background

Geldanamycin is a benzoquinoid ansamycin produced by Streptomyces hygroscopicus. It binds specifically to heat shock protein HSP90 and downregulates target proteins including tyrosine kinases, steroid receptors, transcription factors and cell cycle regulatory kinases (1,2). It induces the inactivation, destabilization and eventual degradation of HIF-1

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Support products are guaranteed for 6 months from date of receipt.