APE1 Redox Inhibitor Summary
E3330 is a chemical that inhibits the redox activity of APE1.
Packaging, Storage & Formulations
Store at -20C in powder form. Store at -80C once reconstituted.
This product is supplied as a powder. It is soluble in DMSO (>20 mg/mL).
Concentration is not relevant for this product. Please see the protocols for proper use of this product.
E3330 is useful for inhibiting APE1 redox activity.
E3330 Chemical Information:
Synonym: (2E)-2-[(4,5-Dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methylene]-undecanoic acid
Molecular Weight: 378.459
Empirical Formula: C21H30O6
CAS Number: 136164-66-4
HPLC purity is >= to 97%
Solubility: DMSO: >20 mg/mL
Please go the "Publications, Images, Reviews & Protocols" tab and look under "General Protocols" for this product's MSDS.
Alternate Names for APE1 Redox Inhibitor
- (2E)-2-[(4,5-Dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methylene]-undecanoic acid
- AP endonuclease 1 Inhibitor
- APE-1 Inhibitor
- APEX 1 Inhibitor
- Apurinic Endonuclase Factor 1 Inhibitor
- REF1 Inhibitor
- REF-1 Inhibitor
E3330 represents a novel class of inhibitor. Unlike other compounds that target APE1, it has been recently reported that E3330 recognizes an alternate, redox active conformation of APE1, and that it potentially inhibits APE1's redox activity by inducing disulfide bond formation. No other compound has been reported to selectively recognize an alternate conformation of APE1 or work through this type of mechanism. Thus, E3330 represents a novel class of inhibitor. E3330 was originally developed as an NFkB inhibitor, but subsequently APE1 was found to bind to E3330 through affinity pull-down experiments using immobilized E3330. In light of later work demonstrating that APE1 regulates the transcriptional activity of NFkB, we now know that E3330 actually works upstream of NFkB by inhibiting APE1. Although many quinone compounds have undesirable properties including susceptibility to Michael additions by nucleophiles, E3330 does not form covalent adducts with APE1 because there is no substituent that can serve as an effective leaving group.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Inhibitors are guaranteed
for 1 year from date of receipt.
Product General Protocols
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