E3330 is a specific chemical inhibitor of the APE1 protein redox domain. Therefore, E3330 inhibits APE-1 redox regulation of transcription factors, but does not affect Ape1 DNA repair activity.
APE1 is a dual functioning protein invloved in DNA repair and redox regulation of transcription factors. The APE1 DNA repair function primarily involves apurinic/apyrimidinic endonuclease DNA base excision repair activity and proofreading exonuclease activity. The protein also modulates DNA binding activity of several transcription factors (NF-®B, Egr-1, p53, AP-1, CREB, HIF-a) and members of the Pax family. APE1 is found overexpressed in several human cancers, and reduced APE1 function has is detrimental to cancer cell viability. Therefore, E3330 has been shown to significantly reduce the growth of human pancreatic cancer cells in vitro and inhibits pancreatic cancer cell migration.
The APE1 inhibitor molecule E3330 is also known as (2E)-2-[(4,5-Dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methylene]-undecanoic acid
- (2E)-2-[(4,5-Dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methylene]-undecanoic acid
- APE-1 Inhibitor
- REF1 Inhibitor
- REF-1 Inhibitor
- Apurinic Endonuclase Factor 1 Inhibitor
- APEX 1 Inhibitor
- AP endonuclease 1 Inhibitor