Aldosterone Antibody

Product Discontinued

Aldosterone Antibody Summary

• Immunogen: Made to Human ALDOSTERONE
• Localization: Secreted
• Specificity: NB100-62321 is specific for Aldosterone. Aldosterone is a steroid hormone which is produced by the adrenal gland. It has a number of functions relating to the kidney nephron including the balance of sodium and potassium, and increasing blood pressure.
  
  It is involved in two disorders: Addison's disease, where it is reduced, and Conn Syndrome, were it is it found in increased amounts.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
• Control:

  CYP11B2 Overexpression Lysate

Reactivity Notes

Rat reactivity reported in scientific literature (PMID: 29257277).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Whole antisera
• Preservative: 0.09% Sodium Azide
• Purity: Unpurified

Alternate Names for Aldosterone Antibody

• Aldosterone

Background

Aldosterone is a steroid hormone (mineralocorticoid family) produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland to regulate sodium and potassium balance in the blood. It is synthesized from cholesterol by aldosterone synthase, which is absent in other sections of the adrenal gland. It acts in the kidney promoting the reabsorption of sodium ions (Na+) into the blood. Water follows the salt and this helps maintain normal blood pressure. It also acts on sweat glands to reduce the loss of sodium in perspiration and taste cells to increase the sensitivity of the taste buds to sources of sodium.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Aldosterone Antibody (NB100-62321)(1)

Publication using NB100-62321

• Li J, Zhang YG, Luo LM et al. Urotensin II promotes aldosterone expression in rat aortic adventitial fibroblasts. Mol Med Rep 2018-02-17 [PMID: 29257277] (ELISA, Rat)