20S Proteasome Antibody (863425) [Unconjugated] Summary
Human 20S Proteasome purified from human erthrocytes
Detects human 20S Proteasome in direct ELISAs.
Test in a species/application not listed above to receive a full credit towards a future purchase.
- Immunohistochemistry 5-25 ug/mL
Packaging, Storage & Formulations
|Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Reconstitute at 0.5 mg/mL in sterile PBS.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for 20S Proteasome Antibody (863425) [Unconjugated]
The 20S Immunoproteasome is a modified form of the
constitutively active 20S Proteasome core particle and is the catalytic subunit
of the multi-complex Immunoproteasome. The structure of the 20S
Immunoproteasome is similar to the 20S Proteasome, which is composed of 28
non-identical subunits arranged into four stacked rings. However, during 20S
Immunoproteasome assembly, the three catalytic beta subunits, beta 1, 2, and 5,
in the two interior rings of the 20S Proteasome are replaced by three
IFN-gamma-inducible catalytic subunits: beta 1i/LMP2, beta 2i/LMP7, and beta
5i/MECL-1. The 20S Immunoproteasome is commonly associated with the 19S, PA28
alpha/beta, or the PA28 gamma regulatory complexes. 20S Immunoproteasome
expression is enriched in antigen presenting cells of the immune system where
the 20S Immunoproteasome selectively degrades intracellular proteins in a
manner that optimizes the generation of peptides for MHC class I antigen
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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