Macrophage Inflammatory Protein 1 alpha Products

Description

Macrophage Inflammatory Protein 1 alpha (MIP1 alpha) and MIP1 beta, two closely related but distinct proteins, were originally co-purified from medium conditioned by a LPS-stimulated murine macrophage cell line. Mature mouse MIP1 alpha shares approximately 77% and 70% amino acid identity with human MIP1 alpha and mouse MIP1 beta, respectively. MIP1 proteins are expressed primarily in T cells, B cells, and monocytes after antigen or mitogen stimulation. Has adhesive effects on lymphocytes. MIP1 alpha can inhibit the proliferation of hematopoietic stem cells in vitro as well as in vivo. A signal transducing receptor, designated the C-C chemokine receptor-1 (C-C CKR-1) with seven transmembrane domains that bind MIP1 alpha, MIP1 beta, MCP1 and RANTES with varying affinities, has been isolated.

Bioinformatics

Entrez	116637 Rat 20302 Mouse 20303 Mouse 6348 Human
Uniprot	NM_002983 Human NP_002974 Human NP_002974.1 Human NP_066286.1 Human P10147 Human P50230 Rat
Product By Gene ID	6348
Alternate Names	C-C motif chemokine 3 chemokine (C-C motif) ligand 3 G0S19-1Tonsillar lymphocyte LD78 alpha protein LD78ALPHA Macrophage inflammatory protein 1-alpha MIP1AG0/G1 switch regulatory protein 19-1 MIP-1-alphaSIS-beta SCYA3PAT 464.1 small inducible cytokine A3 (homologous to mouse Mip-1a) Small-inducible cytokine A3

Research Areas for Macrophage Inflammatory Protein 1 alpha

Find related products by research area and learn more about each of the different research areas below.

Biologically Active Proteins
Cancer
Cytokine Research
Immunology
Innate Immunity
Signal Transduction