Lck Products

Description

The human T-cell or lymphocyte specific gene Lck/p56 is a member of the Src family of non-receptors tyrosine kinase. Mostly expressed in T cells, Lck has been shown to be critical for the normal development of T lymphocytes (1). Additionally, the N-terminal region of the tyrosine kinase Lck interacts with the cytoplasmic domains of CD4 and CD8 (2). Autophosphorylation at Tyr-394 appears to be required for maximum catalytic activity (3) but it can also be suppressed by phosphorylation of the carboxyl-terminal tyrosine Tyr-505 (4).

Bioinformatics

Entrez	16818 Mouse 313050 Rat 3932 Human
Uniprot	AAH13200 Human AAH13200.1 Human NM_005356 Human NP_001036236 Human P06239 Human
Product By Gene ID	3932
Alternate Names	EC 2.7.10 EC 2.7.10.2 Leukocyte C-terminal Src kinase LSK Lymphocyte cell-specific protein-tyrosine kinase lymphocyte-specific protein tyrosine kinase p56(LSTRA) protein-tyrosine kinase p56lck p56-LCK pp58lck Protein YT16 Proto-oncogene Lck proto-oncogene tyrosine-protein kinase LCK T cell-specific protein-tyrosine kinase T-lymphocyte specific protein tyrosine kinase p56lck tyrosine-protein kinase Lck YT16

Research Areas for Lck

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
CD Markers
Cell Cycle and Replication
Immunology
Phospho-Specific
Protein Kinase
Signal Transduction
Tyrosine Kinases