Toll-like Receptor Inhibitors

Toll-like Receptor

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Toll-like Receptor Inhibitors

Both extracellular and intracellular pattern-associated molecular patterns (PAMPs) bind to Toll-like receptors (TLR) and activate downstream TLR signaling pathways via the interaction of TIR domains with adaptor molecules. This leads to NF-kB pathway activation, which in turn induces inflammatory responses. The TLRs and their downstream signaling pathways can be studied with cell permeable inhibitor peptides. Inhibitor peptides block signaling events through decoy action: a realistic replica used as a lure or bait. Each peptide employs a specific decoy mechanism that blocks the propagation of downstream signaling pathways.

Target

Inhibitor

Description

TLR2

TIRAP Inhibitor

Functions as a TIRAP decoy by binding TIR interacting domains on certain TLR receptors. Inhibits TIRAP-TLR2 and TIRAP-TLR4.

TLR4

TIRAP Inhibitor

VIPER Inhibitor

Functions as a TIRAP decoy by binding TIR interacting domains on certain TLR receptors. Inhibits TIRAP-TLR2 and TIRAP-TLR4.

Binds TIRAP-TLR4 and TRAM-TLR4, inhibiting TLR4 activation.

MyD88

MyD88 Inhibitor

Functions as a decoy by binding the MyD88 TIR domain.

IKK-gamma

IKK-gamma Inhibitor

Functions as a IKK-alpha and IKK-beta decoy by binding to IKK-gamma, preventing formation of the IKK complex.

NfKB p65 (pSer276)

NfKB p65 Inhibitor

Functions as a p65 decoy through phosphorylation of Ser276 on the peptide.

NfKB p65 (pSer529/536)

NfKB p65 Inhibitor

Functions as a p65 decoy through phosphorylation of Ser529/536 on the peptide.

NfKB p105/p50 (pSer105/p50)

NfKB p50 Inhibitor

Functions as a p65 decoy by blocking the intracellular recognition mechanism of p50 NLS.



Toll-like Receptor

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