IkB-beta Products

Description

Three major forms of IkB-like molecules have been identified and each is characterized by multiple copies of ankyrin repeats. IkB-alpha and IkB-beta appear to be the major regulatory forms of IkB in most cells. These proteins interact with p65 or c-Rel containing forms of NFkB and block nuclear import by masking the nuclear localization sequences of NFkB. The activation of NFkB involves the inducible phosphorylation and subsequent degradation of IkB. Immunoblotting easily detects the hyper-phosphorylated forms of IkB-alpha, but not phosphorylated IkB-beta. Interestingly, IkB-alpha and IkB-beta mediate different NFkB responses. IkB-alpha appears to control more transient activation of NFkB in response to an inducer, while IkB-beta controls a persistent response. Bcl-3 interacts with p50 and p52 containing forms of NFkB, but rather than being an inhibitor it appears to function to stimulate transcription. The degradation of IkB is confirmed by immunoblotting.

Bioinformatics

Entrez	4793 Human 18036 Mouse 81525 Rat
Uniprot	Q15653
Product By Gene ID	4793
Alternate Names	beta IkappaBbeta I-kappa-B-beta IkB-B IkBbeta IkB-beta IKBBikB-beta NF-kappa-B inhibitor beta NF-kappa-BIB NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor Thyroid receptor-interacting protein 9 TR-interacting protein 9 TRIP-9 TRIP9ikappaBbeta

Research Areas for IkB-beta

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Immunology
Innate Immunity