FKBP12 Products

Description

Immunophilins are a family of soluble receptors capable of binding to one of two major immunosuppressant agents; cyclosporin A (CsA) or FK506. Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs) and those that bind cyclosporin A are called cyclophilins (CyP). Immunophilins function as cis-trans peptidyl-prolyl isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. Thus, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline-containing proteins.FKBP12:FK506 complexes inhibit calcineurin, a calcium/calmodulin-dependent serine/threonine phosphatase which blocks T-cell activation by preventing lymphokine gene transcription. FKBP12 also plays a role in intracellular calcium regulation by associating with three types of calcium release channel complexes, cardiac and skeletal ryanodine receptors and the inositol 1,4,5-trisphosphate receptor. In interactions with members of the TGF beta family type I receptors, FKBP12 has been shown to exert an inhibitory effect on the signaling pathway.

Bioinformatics

Entrez	14225 Mouse 2280 Human 25639 Rat
Uniprot	AAH05147 Human NM_000801 Human NM_054014 Human NP_000792 Human NP_463460 Human P62942 Human
Product By Gene ID	2280
Alternate Names	12 kDa FKBP EC 5.2.1.8 FK506 binding protein 1A, 12kDa FK506-binding protein 1A FKBP1 FKBP12C FKBP12FKBP12-Exip3 FKBP-12T-cell, 12-kD FKBP-1A peptidyl-prolyl cis-trans isomerase FKBP1A PPIase FKBP1A protein kinase C inhibitor 2 rotamase Rotamase

Research Areas for FKBP12

Find related products by research area and learn more about each of the different research areas below.

Autophagy
Cancer
mTOR Pathway