ZMPSTE24 Products

Antibodies
ZMPSTE24 Antibody
ZMPSTE24 Antibody
NBP1-84755
Species: Hu, Rat
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Proteins
ZMPSTE24 Peptide
ZMPSTE24 Peptide
NB100-2388PEP
Species: Hu
ZMPSTE24 Peptide
ZMPSTE24 Peptide
NB100-2387PEP
Species: Hu
ZMPSTE24 Partial Recombinant ...
ZMPSTE24 Partial Recombinant Protein
H00010269-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
ZMPSTE24 RNAi
ZMPSTE24 RNAi
H00010269-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

ZMPSTE24, also known as FACE1, is a zinc metalloprotease involved in the post-translational processing of Lamin A/C precursors. Specifically, ZMPSTE-24 proteolytically removes the C-terminal three residues of the farnesylated Lamin proteins.

FACE-1 is widely expressed, with the highest levels found in the kidney, prostate, testis and ovary.

Mutations in ZMPSTE24 have been associated with human diseases such as mandibuloacral dysplasia with type B lipodystrophy (MADB) and lethal tight skin contracture syndrome (LTSCS), often due to the accumulation of LMNA precursors. It is theorized that ZMPSTE24 may play an important role in human ageing, based on its association with LMNA.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Human
Product By Gene ID 10269
Alternate Names
  • zona pellucida-binding protein 2
  • ZPBP-like protein
  • ZPBPLMGC41930
  • zona pellucida binding protein 2

Research Areas for ZMPSTE24

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
Cell Biology
Cytoskeleton Markers
Extracellular Matrix
Signal Transduction
Ubiquitin Proteasome Pathway

Bioinformatics Tool for ZMPSTE24

Discover related pathways, diseases and genes to ZMPSTE24. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related ZMPSTE24 Blog Posts

Check out the latest blog posts on ZMPSTE24.
ZMPSTE24 Mutations, Lamin A Processing & Laminopathies
ZMPSTE24 (FACE-1, CAAX prenyl protease 1 homolog) is a membrane associated zinc metalloprotease of the peptidase M48A family. It's catalytic activity can be defined as the peptide bond hydrolyzed in the sequence -C-|-A-A-X in which C is an S-isoprenyl...    Read more.
Read more ZMPSTE24 related blogs.