Z-LE(OMe)HD(OMe)-FMK Products

Description

Members of the caspase family play key roles in apoptosis and inflammation. Z-LE(OMe)HD(OMe)-FMK is a cellpermeable caspase peptide inhibitor that irreversibly binds to the catalytic site of caspases proteases, and inhibits caspase mediated apoptosis by preventing the processing of pro-caspases to their active forms (reviewed in 1-3). ZLEHD- FMK was first described is an irreversible and cell permeable inhibitor of Caspase 9. The Z-LE(OMe)HD(OMe)-FMK peptide is O-methylated in the P1 and P3 positions providing enhanced stability and increased cell permeability. Z-LE(OMe)HD(OMe)-FMK (Z-LEHD-FMK) is typically used in assays to inhibit apoptosis. Z-LEHD-FMK has been used in many different types of apoptosis assays and published using a number of model system. Users may want to consult the literature for additional information regarding applications for Z-LEHDFMK. Z-LEHD-FMK is recommended as a search term for identifying references in PubMed using this peptide inhibitor.

Bioinformatics

Alternate Names

Z-LE(OMe)HD(OMe)-FMK Z-LEHD-FMK [Z-Leu-Glu(OMe)-His-Asp(OMe)-FMK Z-LEHD-FMK Z-Leu-Glu(OMe)-His-Asp(OMe)-FMK.