Z-LE(OMe)HD(OMe)-FMK (Caspase 9 Inhibitor)


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Applications In vitro

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Z-LE(OMe)HD(OMe)-FMK (Caspase 9 Inhibitor) Summary

Z-Leu-Glu(OMe)-His-Asp(OMe)-FMK TFA Caspase Inhibitor
Details of Functionality
Molecular Weight: 690 (not including TFA salt)
Formula: C32H43N6O10F
Mass Spec: M+1=691.2
TLC: B:8, A:1, W:1, Rf:065
NMR: All functional groups are present


  • In vitro assay
Application Notes
1. This inhibitor is designed as a methyl ester to facilitate cell permeability. If the intended use is on purified or recombinant enzymes, esterase should be added to generate the free carboxyl groups. Please contact us for more details.
2. For in-vivo or in-vitro experiments extending longer than 12 hrs, fresh inhibitor may have to be added toculture medium or injected into animals.

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Form: Tan crystals, (crystalline gel)
Store well desiccated and under nitrogen, very hygroscopic
For extra precaution, store the solid product under a blanket of nitrogen because it is hygroscopic material.

Alternate Names for Z-LE(OMe)HD(OMe)-FMK (Caspase 9 Inhibitor)

  • Z-LE(OMe)HD(OMe)-FMK
  • Z-LEHD-FMK [Z-Leu-Glu(OMe)-His-Asp(OMe)-FMK
  • Z-Leu-Glu(OMe)-His-Asp(OMe)-FMK.


Members of the caspase family play key roles in apoptosis and inflammation. Z-LE(OMe)HD(OMe)-FMK is a cellpermeable caspase peptide inhibitor that irreversibly binds to the catalytic site of caspases proteases, and inhibits caspase mediated apoptosis by preventing the processing of pro-caspases to their active forms (reviewed in 1-3). ZLEHD- FMK was first described is an irreversible and cell permeable inhibitor of Caspase 9. The Z-LE(OMe)HD(OMe)-FMK peptide is O-methylated in the P1 and P3 positions providing enhanced stability and increased cell permeability. Z-LE(OMe)HD(OMe)-FMK (Z-LEHD-FMK) is typically used in assays to inhibit apoptosis. Z-LEHD-FMK has been used in many different types of apoptosis assays and published using a number of model system. Users may want to consult the literature for additional information regarding applications for Z-LEHDFMK. Z-LEHD-FMK is recommended as a search term for identifying references in PubMed using this peptide inhibitor.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Inhibitors are guaranteed for 1 year from date of receipt.

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