Z-IE(OMe)TD(OMe)-FMK Products

Description

Members of the caspase family play key roles in apoptosis and inflammation. Z-IE(OMe)TD(OMe)-FMK is a cell-permeable caspase peptide inhibitor that irreversibly binds to the catalytic site of caspases proteases, and inhibits caspase mediated apoptosis by preventing the processing of pro-caspases to their active forms (reviewed in 1-3). Z-IETD-FMK was first described is an irreversible and cell permeable inhibitor of Caspase 8. The Z-IE(OMe)TD(OMe)-FMK peptide is O-methylated in the P1 and P3 positions providing enhanced stability and increased cell permeability. Z-IE(OMe)TD(OMe)-FMK (Z-IETD-FMK) is typically used in assays to inhibit apoptosis. Z-IETD-FMK has been used in many different types of apoptosis assays and published using a number of model system. Users may want to consult the literature for additional information regarding applications for Z-IETD D-FMK. Z-IETD-FMK is recommended as a search term for identifying references in PubMed using this peptide inhibito

Bioinformatics

Alternate Names

C30H43N4O11F Z-IE(OMe)TD(OMe)-FMK Z-IETD-FMK Z-IETD-FMK [Z-Ile-Glu(OMe)-Thr-Asp(OMe)-FMK