XTP4 Products

Description

During the past decade the role of the ERBB2 (neu/HER2) oncogene as an important predictor of patient outcome and response to various therapies in breast cancer has been clearly established. The C35 (C17orf37) is a novel tumor biomarker abundantly expressed in breast cancer. Identification of shared tumor-specific targets is useful in developing broadly applicable therapies. The C35 gene is located on chromosome 17q12, 505 nucleotides from the 3' end of the ERBB2 oncogene, the antigenic target for trastuzumab (Herceptin) therapy. The chromosomal arrangement of the genes encoding C35 and ERBB2 is tail to tail. The ORF 37 open reading frame encodes a 12-kDa protein of unknown function.

Bioinformatics

Uniprot	Q9BRT3 Human
Product By Gene ID	84299
Alternate Names	C35 chromosome 17 open reading frame 37 HBV XAg-transactivated protein 4 HBV X-transactivated gene 4 protein MGC14832 ORB3 protein C17orf37 Protein C35 XTP4RDX12