VPS34 Products

VPS34 Antibody
VPS34 Antibody
Species: Hu, Mu, Rt, Po
Applications: WB, Simple Western, ICC/IF
Host: Rabbit Polyclonal
VPS34 Antibody
VPS34 Antibody
Species: Hu, Mouse, Rat
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
VPS34 Antibody
VPS34 Antibody
Species: Hu
Applications: WB, ELISA
Host: Mouse Polyclonal
VPS34 Overexpression Lysate ( ...
VPS34 Overexpression Lysate (Native)
Applications: WB
VPS34 Overexpression Lysate ( ...
VPS34 Overexpression Lysate (Denat...
Applications: WB
VPS34 Recombinant Protein
VPS34 Recombinant Protein
Species: Hu
Applications: WB, ELISA, PA
VPS34 Recombinant Protein Ant ...
VPS34 Recombinant Protein Antigen
Species: Hu
Applications: B/N, Ctrl
Species: Hu


VPS34, also known as phosphoinositide-3-kinase p100 subunit or PIK3C3 (phosphoinositide-3-kinase, class III), is a member of the PI3/PI4-kinase family. It is ubiquitously expressed with predominant expression in skeletal muscle and is believed to participate in endosome to lysosome transport, multivesicular body formation, autophagy and retrograde endosome to Golgi transport. VPS34 is the catalytic subunit of class III PI3Ks and forms a heterodimer with p150, a regulatory subunit of class 3 PI3Ks. It exclusively phosphorylates phosphatidylinositol to produce PtdIns3P. The activity of VPS34 is enhanced by manganese and can be regulated by nutrients, suggesting an important role of VPS34 in the regulation of mTOR protein synthesis. VPS34 also forms a complex with Beclin1 that promotes autophagy and tumor supression.


Entrez Human
Uniprot Human
Product By Gene ID 5289
Alternate Names
  • PtdIns-3-kinase type 3
  • EC 2.7.1
  • PI3K type 3
  • Phosphoinositide-3-kinase class 3
  • PI3-kinase type 3
  • phosphatidylinositol 3-kinase catalytic subunit type 3
  • hVps34
  • MGC61518
  • VPS34
  • Vps34
  • Phosphatidylinositol 3-kinase p100 subunit
  • EC
  • phosphoinositide-3-kinase, class 3

Research Areas for VPS34

Find related products by research area and learn more about each of the different research areas below.

Innate Immunity
Signal Transduction

PTMs for VPS34

Learn more about PTMs related to VPS34.


Bioinformatics Tool for VPS34

Discover related pathways, diseases and genes to VPS34. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Vizit™, under license from BioVista Inc.

Related VPS34 Blog Posts

Check out the latest blog posts on VPS34.
UVRAG - A regulator of membrane trafficking in autophagy and endocytosis
UV resistance-associated gene (UVRAG) is a tumor suppressor that is commonly mutated in colon and breast cancer. While UVRAG was discovered for its ability to complement UV sensitivity in xeroderma pigmentosum cells, its main functions are in auto...    Read more.
VPS34 - autophagy initiator and regulator of endosomal trafficking
VPS34, vacuolar protein sorting 34, is the only identified Class III phosphoinositide-3 kinase (PI3K) in mammals and is ubiquitously expressed in all eukaryotic cells. VPS34 is a 100 kDa protein responsible for phosphorylating phosphatidylinositol...    Read more.
ULK1 - mammalian homologue of the yeast ATG1 kinase
Autophagy is an important cellular process involved in degradation and recycling of cellular macromolecules in response to stress or starvation. Autophagy is carried out in four main phases: phagophore nucleation, autophagosome elongation, docking...    Read more.
VPS41 - An important regulator of lysosomal trafficking
Membrane fusion is an essential step during the trafficking of endosomes and vesicles throughout the cell. Membrane fusion events are facilitated by multisubunit tethering complexes (MTC) including CORVET and HOPS. These complexes interact with Rab...    Read more.
Beclin 2, a mammal-specific homolog of Beclin 1 with unique functional similarities and differences
Beclin 2 (BECN2) is also called Beclin-1-like protein 1/ BECN1P1 and it was recently identified by He et al 2013 as a mammal-specific homolog of the evolutionarily conserved protein Beclin 1 which is well established for its role in the regulation...    Read more.
Beclin 1 - a key regulator of autophagosome formation
The Beclin 1 protein is a central regulator of autophagy in mammalian cells. Autophagy is an essential process used to maintain cellular homeostasis by degrading and recycling cellular components such as damaged or worn out organelles and macromole...    Read more.
ATG9A - early marker autophagosome assembly
ATG9A is the only essential integral membrane protein involved in autophagy. ATG9A contains six transmembrane domains and initiates the assembly of autophagosomes. The autophagosome is a double-membrane structure that engulfs and eventually degrade...    Read more.
Read more VPS34 related blogs.