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Vasoactive intestinal peptide receptor 2 (VPAC2) belongs to a family of three G protein-coupled receptors, which includes the related protein, VPAC1, and the pituitary adenylate cyclase-activating peptide receptor (PAC1). VPAC2 mediates the biological functions of the neuropeptide, vasoactive intestinal polypeptide (VIP), and, but with lower affinity, pituitary adenylate cyclase-activating peptide (PACAP), which are widely distributed throughout the brain and periphery.