Species: Hu
Applications: WB
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Host: Mouse Polyclonal
Species: Hu
Applications: WB
Description
Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that the selectivelyubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediateddegradation. Inactivation of VHL causes VHL disease and sporadic kidney cancer. This gene encodes a VHL homolog thatlacks one of two key domains necessary for VHL function. It binds HIF alpha but fails to recruit the E3 ubiquitinligase complex, and therefore functions as a dominant-negative VHL and a protector of HIF alpha. This gene isintronless and predominantly expressed in the placenta, and may contribute to the regulation of oxygen homeostasis andneovascularization during placenta development. (provided by RefSeq)
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
|
| Product By Gene ID |
391104 |
| Alternate Names |
- VHL-like protein
- VHLP
- VLPVHL pseudogene
- von Hippel-Lindau tumor suppressor-like
- von Hippel-Lindau-like protein
|
