VHLL Products

Antibodies
VHLL Antibody
VHLL Antibody
H00391104-B01P-50ug
Species: Hu
Applications: WB
Host: Mouse Polyclonal
Lysates
VHLL Overexpression Lysate (N ...
VHLL Overexpression Lysate (Native)
NBL1-17720
Applications: WB

Description

Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that the selectivelyubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediateddegradation. Inactivation of VHL causes VHL disease and sporadic kidney cancer. This gene encodes a VHL homolog thatlacks one of two key domains necessary for VHL function. It binds HIF alpha but fails to recruit the E3 ubiquitinligase complex, and therefore functions as a dominant-negative VHL and a protector of HIF alpha. This gene isintronless and predominantly expressed in the placenta, and may contribute to the regulation of oxygen homeostasis andneovascularization during placenta development. (provided by RefSeq)

Bioinformatics

Entrez Human
Uniprot Human
Product By Gene ID 391104
Alternate Names
  • von Hippel-Lindau-like protein
  • VHLP
  • VHL-like protein
  • VLPVHL pseudogene
  • von Hippel-Lindau tumor suppressor-like

Bioinformatics Tool for VHLL

Discover related pathways, diseases and genes to VHLL. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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