VAV2 Products

Antibodies
VAV2 Antibody
VAV2 Antibody
NBP2-27078
Species: Hu, Ca, Pm
Applications: WB
Host: Rabbit Polyclonal
VAV2 Antibody
VAV2 Antibody
NBP1-19661
Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
VAV2 Antibody
VAV2 Antibody
NBP1-86520
Species: Hu, Mouse, Rat
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
VAV2 Overexpression Lysate (N ...
VAV2 Overexpression Lysate (Native)
NBL1-17702
Applications: WB
Proteins
VAV2 Recombinant Protein Anti ...
VAV2 Recombinant Protein Antigen
NBP1-86520PEP
Species: Hu
Applications: AC
RNAi
VAV2 RNAi
VAV2 RNAi
H00007410-R01
Species: Hu

Description

The Vav family are Rho/Rac guanosine nucleotide exchange factors (GEFs), consisting of three members in mammalian cells (Vav, Vav2, Vav3) and one in nematodes (CelVav) (1). Vav and Vav2 are members of the dbl family of guanine nucleotide exchange factors (GEF) for the rho/rac family of GTP binding proteins. Vav is expressed primarily in hematopoietic cells, while vav2 has a wider tissue distribution (2). Vav2 serves as a guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Unlike Vav1, whose expression is restricted to cells of hematopoietic origin, Vav2 is broadly expressed. Recently, Vav2 has been identified as a substrate for the epidermal growth factor (EGF) receptor. EGF receptor phosphorylates Vav2 on all three possible phosphorylation sites, Tyr-142, Tyr-159, and Tyr-172. results suggest that EGF regulates Vav2 activity basically through phosphatidylinositol 3-kinase activation, whereas tyrosine phosphorylation of Vav2 may rather be necessary for mediating protein-protein interactions (3)

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Product By Gene ID 7410
Alternate Names
  • Protein vav-2
  • VAV-2
  • oncogene VAV2
  • vav 2 oncogene
  • guanine nucleotide exchange factor VAV2
  • vav 2 guanine nucleotide exchange factor

Research Areas for VAV2

Find related products by research area and learn more about each of the different research areas below.

Signal Transduction

PTMs for VAV2

Learn more about PTMs related to VAV2.

Phosphorylation
Ubiquitination
Reduction
Dephosphorylation
Methylation

Bioinformatics Tool for VAV2

Discover related pathways, diseases and genes to VAV2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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