VAMP-1 Products

Description

The Vesicle Associated Membrane Proteins (VAMP) or synaptobrevins are calcium binding proteins specific to eukaryotes. VAMPs, along with synaptosomal associated protein of 25 kDa (SNAP-25) and syntaxin, form the core complex of soluble NSF attachment protein receptor (SNARE) proteins that interact with the soluble proteins N-ethylmaleimide-sensitive factor (NSF) and alpha-SNAP. These membrane associated proteins play a key role in the regulation of vesicle membrane fusion with the plasma membrane. The Clostridium tetani neurotoxin is a metalloprotease with specificity for VAMP. In Alzheimer®s disease, VAMP levels of all isoforms appear to be significantly lowered. It has been shown that the extreme carboxy-terminus of VAMP-1 is involved in subcellular vesicle targeting.

Bioinformatics

Entrez	22317 Mouse 25624 Rat 6843 Human
Uniprot	NM_199245 Human NP_055046 Human NP_058439 Human P23763 Human Q63666 Rat
Product By Gene ID	6843
Alternate Names	DKFZp686H12131 SYB1vesicle-associated membrane protein 1 synaptobrevin 1 Synaptobrevin-1 VAMP-1synaptobrevin-1 vesicle-associated membrane protein 1 (synaptobrevin 1)

Diseases related to VAMP-1

Discover more about diseases related to VAMP-1.

Disease Of Adrenal Medulla
Tetanus
Nervousness
Wasting Syndrome
Schizophrenia
Nervous System Disorder
Burkitt Lymphoma
Varicosity
Malignant Neoplasm Of Breast
Ataxia
Strabismus
Glioma
Spastic Paraplegia, Hereditary
Botulism
Iron Metabolism Disorders
Patient Dependence On
Paraplegia
Malignant Neoplasms

Pathways for VAMP-1

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Exocytosis
Secretion
Localization
Membrane Fusion
Transport
Vesicle Docking
Vesicle Fusion
Hormone Secretion
Peptide Hormone Secretion
Synaptic Transmission
Regeneration
Synaptic Vesicle Exocytosis
Clathrin-mediated Endocytosis
Endoplasmic Reticulum Localization
Catecholamine Secretion
Fertilization
Snare Complex Assembly
Cytokinesis
Neuromuscular Synaptic Transmission
Vesicle Targeting

Research Areas for VAMP-1

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Membrane Trafficking and Chaperones
Membrane Vesicle Markers
Neuronal Cell Markers
Neuroscience

PTMs for VAMP-1

Learn more about PTMs related to VAMP-1.

Cleavage
Biotinylation
Acetylation
Prenylation

Bioinformatics Tool for VAMP-1

Discover related pathways, diseases and genes to VAMP-1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.