UBA3 Products

Description

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Bioinformatics

Entrez	117553 Rat 22200 Mouse 9039 Human
Uniprot	AAH22853 Human NM_003968 Human NM_198195 Human NP_003959 Human Q8TBC4 Human
Product By Gene ID	9039
Alternate Names	DKFZp566J164 EC 6.3.2 EC 6.3.2.- hUba3 hUBA3 MGC22384 NEDD8-activating enzyme E1 catalytic subunit NEDD8-activating enzyme E1C Nedd8-activating enzyme hUba3 UBA3, ubiquitin-activating enzyme E1 homolog UBE1C Ubiquitin-activating enzyme 3 ubiquitin-activating enzyme E1C (homologous to yeast UBA3) Ubiquitin-activating enzyme E1C ubiquitin-like modifier activating enzyme 3 Ubiquitin-like modifier-activating enzyme 3 yeast)

Research Areas for UBA3

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cell Cycle and Replication
Neuroscience