UBA3 Products

Description

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq]. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Bioinformatics

Product By Gene ID

9039

Alternate Names

DKFZp566J164 EC 6.3.2 EC 6.3.2.- hUBA3 MGC22384 NEDD8-activating enzyme E1 catalytic subunit NEDD8-activating enzyme E1C Nedd8-activating enzyme hUba3 UBA3 UBA3, ubiquitin-activating enzyme E1 homolog UBE1C Ubiquitin-activating enzyme 3 ubiquitin-activating enzyme E1C (homologous to yeast UBA3) Ubiquitin-activating enzyme E1C ubiquitin-like modifier activating enzyme 3 Ubiquitin-like modifier-activating enzyme 3 yeast)

Research Areas for UBA3

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
Neuroscience