TRPM7 Products

Description

TRPCs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants.; FUNCTION: Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1). CATALYTIC ACTIVITY: ATP + a protein: ADP + a phosphoprotein. COFACTOR: Binds 1 zinc ion per subunit. SUBUNIT: Homodimer. Forms heterodimers with TRPM6. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.

Bioinformatics

Entrez	54822 Human 58800 Mouse
Uniprot	Q96QT4 Mouse
Product By Gene ID	54822
Alternate Names	CHAK CHAK1FLJ25718 Channel-kinase 1 EC 2.7.11.1 Long transient receptor potential channel 7 LTRPC ion channel family member 7 LTrpC7 LTrpC-7 LTRPC7FLJ20117 transient receptor potential cation channel subfamily M member 7 transient receptor potential cation channel, subfamily M, member 7 transient receptor potential-phospholipase C-interacting kinase TRP-PLIK

Research Areas for TRPM7

Find related products by research area and learn more about each of the different research areas below.

Neurodegeneration
Neuronal Cell Markers
Neuroscience

Related TRPM7 Blog Posts

Check out the latest blog posts on TRPM7.

Winter is coming, and TRPM8 welcomes the cold! TRPM8, or transient receptor potential melastatin 8, is a nonselective cation channel that is activated by cold environments and menthol-like cooling compounds.  While TRPM8 is best known for its location in peripheral nerve endings, it has functio...    Read more.

Read more TRPM7 related blogs.