Hu, Mu, Rt, BvApplications:
WB, ELISA, ICC/IF, IHC, IHC-PHost:
Applications: WB, IHC, IHC-Fr, IHC-P
Host: Rabbit Polyclonal
Applications: WB, Flow, IHC, IHC-P
Host: Mouse Monoclonal
Applications: WB, ELISA, PA, PAGE, AP
TREX1 encodes the major 3'->5' DNA exonuclease in human cells. The protein is a non-processive exonuclease that may serve a proofreading function for a human DNA polymerase. It is also a component of the SET complex, and acts to rapidly degrade 3' ends of nicked DNA during granzyme A-mediated cell death. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
|Product By Gene ID
- Aicardi-Goutieres syndrome 1
- EC 18.104.22.168
- DNase III
- 3'-5' exonuclease TREX1
- three prime repair exonuclease 1,3' repair exonuclease 1
Bioinformatics Tool for TREX1
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Related TREX1 Blog Posts
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|Dinosaur Protein Names: Infographic
Trex1 the protein is involved in DNA damage response. Tyrannosaurus rex (T. rex) the dinosaur lived during the Cretaceous Period. Raptor the protein is a regulator of mTOR activity. Velociraptors the dinosaurs lived during the Cretaceous Period. Learn... Read more.
|Trex1 (3'-5' exonuclease TREX1, DNase III)
This gene encodes the major 3' to 5' DNA exonuclease in human cells. The protein is a non-processive exonuclease that appears to provide proofreading for checkpoint signaling after DNA damage in response to oxidative stress and apoptosis. It is ubiqui... Read more.