TREX1 Products

TREX1 Antibody
TREX1 Antibody
Species: Hu, Mu, Rt, Bv
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
TREX1 Antibody
TREX1 Antibody
Species: Hu
Applications: WB, IHC, IHC-Fr, IHC-P
Host: Rabbit Polyclonal
TREX1 Overexpression Lysate
TREX1 Overexpression Lysate
Species: Hu
Applications: WB
Recombinant Human TREX1 Prote ...
Recombinant Human TREX1 Protein
Species: Hu
Applications: WB, ELISA, PA, PAGE, AP
TREX1 Blocking Peptide
TREX1 Blocking Peptide
Species: Hu
Applications: AC
TREX1 Recombinant Protein Ant ...
TREX1 Recombinant Protein Antigen
Species: Hu
Applications: AC


TREX1 encodes the major 3'->5' DNA exonuclease in human cells. The protein is a non-processive exonuclease that may serve a proofreading function for a human DNA polymerase. It is also a component of the SET complex, and acts to rapidly degrade 3' ends of nicked DNA during granzyme A-mediated cell death. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]


Entrez Human
Uniprot Human
Product By Gene ID 11277
Alternate Names
  • Aicardi-Goutieres syndrome 1
  • EC
  • CRV
  • AGS1
  • DNase III
  • 3'-5' exonuclease TREX1
  • DKFZp434J0310
  • DRN3
  • three prime repair exonuclease 1,3' repair exonuclease 1

Research Areas for TREX1

Find related products by research area and learn more about each of the different research areas below.

DNA Repair
Editing and Processing Endonucleases

PTMs for TREX1

Learn more about PTMs related to TREX1.


Bioinformatics Tool for TREX1

Discover related pathways, diseases and genes to TREX1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Vizit™, under license from BioVista Inc.

Related TREX1 Blog Posts

Check out the latest blog posts on TREX1.
Dinosaur Protein Names: Infographic
Trex1 the protein is involved in DNA damage response. Tyrannosaurus rex (T. rex) the dinosaur lived during the Cretaceous Period. Raptor the protein is a regulator of mTOR activity. Velociraptors the dinosaurs lived during the Cretaceous Period. Learn...    Read more.
Trex1 (3'-5' exonuclease TREX1, DNase III)
This gene encodes the major 3' to 5' DNA exonuclease in human cells. The protein is a non-processive exonuclease that appears to provide proofreading for checkpoint signaling after DNA damage in response to oxidative stress and apoptosis. It is ubiqui...    Read more.
Read more TREX1 related blogs.