TREX1 Products

Description

TREX1 encodes the major 3'->5' DNA exonuclease in human cells. The protein is a non-processive exonuclease that may serve a proofreading function for a human DNA polymerase. It is also a component of the SET complex, and acts to rapidly degrade 3' ends of nicked DNA during granzyme A-mediated cell death. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Bioinformatics

Product By Gene ID	11277
Alternate Names	3'-5' exonuclease TREX1 AGS1 Aicardi-Goutieres syndrome 1 CRV DKFZp434J0310 DNase III DRN3 EC 3.1.11.2 HERNS three prime repair exonuclease 1,3' repair exonuclease 1

Research Areas for TREX1

Find related products by research area and learn more about each of the different research areas below.

DNA Repair
Editing and Processing Endonucleases

Related TREX1 Blog Posts

Check out the latest blog posts on TREX1.

Dinosaur Protein Names: Infographic Trex1 the protein is involved in DNA damage response. Tyrannosaurus rex (T. rex) the dinosaur lived during the Cretaceous Period. Raptor the protein is a regulator of mTOR activity. Velociraptors the dinosaurs lived during the Cretaceous Period. Learn...    Read more.

Trex1 (3'-5' exonuclease TREX1, DNase III) This gene encodes the major 3' to 5' DNA exonuclease in human cells. The protein is a non-processive exonuclease that appears to provide proofreading for checkpoint signaling after DNA damage in response to oxidative stress and apoptosis. It is ubiqui...    Read more.

Read more TREX1 related blogs.