Species: Hu, Mu, Bv, Ca, Pm, Rb
Applications: WB, Flow, ICC/IF, IHC, IP, MA, CyTOF-ready
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Applications: WB
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB
Host: Rabbit Polyclonal
Species: Rt
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Mu
Applications: ELISA
Species: Hu
Applications: WB, ELISA, MA, AP
Description
Transportin 1 is the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in two transcript variants encoding different proteins. In cases of HIV-1 infections, transportin 1 is known to bind and mediate the nuclear import of HIV-1 Rev. Heterogeneous nuclear ribonucleoprotein hnRNPA1 is an abundant nuclear protein that plays an important role in pre-mRNA processing and mRNA export from the nucleus. A1 shuttles rapidly between the nucleus and the cytoplasm, and a 38-amino acid domain, M9, serves as the bi-directional transport signal of A1. Recently, a 90-kD protein, transportin, was identified as the mediator of A1 nuclear import. Transportin mediates the nuclear import of additional hnRNP proteins, including hnRNPF. The nuclear localization of A1 is dependent on ongoing RNA polymerase II transcription.
Bioinformatics
| Entrez |
Human
|
| Product By Gene ID |
3842 |
| Alternate Names |
- importin beta 2
- Importin beta-2
- IPO2
- karyopherin (importin) beta 2
- MIP1Karyopherin beta-2
- MIPM9 region interaction protein
- transportin 1
- transportin-1
- TRNKPNB2importin 2
|
