Topo III beta Products

Description

Topo III beta encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Alternative splicing of the C-terminus of this gene results in three transcript variants which have distinct tissue specificity; however, not all variants have been fully described.

Bioinformatics

Product By Gene ID	8940
Alternate Names	DNA topoisomerase 3-beta-1 DNA topoisomerase III beta-1 EC 5.99.1.2 FLJ39376 TOP3B1 topoisomerase (DNA) III beta topoisomerase III beta

Research Areas for Topo III beta

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cell Cycle and Replication
Core ESC-Like Genes
DNA Double Strand Break Repair
DNA Repair
Hypoxia
Stem Cell Markers
Transcription Factors and Regulators
Tumor Suppressors