TMPRSS3 Products

Antibodies
TMPRSS3 Antibody
TMPRSS3 Antibody
NB100-77342
Species: Hu
Applications: WB, PEP-ELISA
Host: Goat Polyclonal
TMPRSS3 Antibody (2E1)
TMPRSS3 Antibody (2E1)
H00064699-M01
Species: Hu
Applications: WB, ELISA
Host: Mouse Monoclonal
Lysates
TMPRSS3 Overexpression Lysate ...
TMPRSS3 Overexpression Lysate (Nat...
NBP2-09933
Applications: WB
TMPRSS3 Overexpression Lysate ...
TMPRSS3 Overexpression Lysate (Nat...
NBP2-06028
Applications: WB
TMPRSS3 Overexpression Lysate ...
TMPRSS3 Overexpression Lysate (Nat...
NBP2-06030
Applications: WB
RNAi
TMPRSS3 RNAi
TMPRSS3 RNAi
H00064699-R07
Species: Hu
TMPRSS3 RNAi
TMPRSS3 RNAi
H00064699-R08
Species: Hu
TMPRSS3 RNAi
TMPRSS3 RNAi
H00064699-R05
Species: Hu

Description

Extracellular proteases mediate the digestion of neighboring extracellular matrix components in initial tumor growth, allow desquamation of tumor cells into the surrounding environment, provide the basis for invasion of basement membranes in targeted metastatic organs and are required for release and activation of many growth and angiogenic factors. The TMPRSS3 (also known as ECHOS1) gene, which encodes a transmembrane serine protease, has been found to be responsible for two non-syndromic recessive deafness loci located on human chromosome 21q22.3, DFNB8 and DFNB10.TMPRSS3, a 437 amno acid membrane bound serine protease and a member of the S1 peptidase family. TMPRSS3 contains an amino-terminal signalanchor sequence and a glycosylated extracellular region containing the serine protease domain. Two novel missense mutations of TMPRSS3, W251C and P404L, alter the highly conserved amino acids of the serine protease domain. TMPRSS3 is expressed in many tissues, including fetal cochlea, a subset of pancreatic cancer and various other cancer tissues. TMPRSS3 is also overexpressed in cancer, suggesting that it may be important for processes in metastasis formation and tumor invasion.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Human
Product By Gene ID 64699
Alternate Names
  • DFNB8
  • EC 3.4.21
  • DFNB10
  • EC 3.4.21.-
  • TADG12
  • transmembrane protease serine 3
  • Tumor-associated differentially-expressed gene 12 protein
  • serine protease TADG12
  • gene similar to transmembrane serine protease10ECHOS1Serine protease TADG-12
  • transmembrane protease, serine 3

Pathways for TMPRSS3

View related products by pathway and learn more about each of the pathways below.

Transport
Methylation
Translation
Dna Hypomethylation
Proteolysis
Interferon-gamma Production
Dna Methylation
Localization
Secretion

Research Areas for TMPRSS3

Find related products by research area and learn more about each of the different research areas below.

Cancer

PTMs for TMPRSS3

Learn more about PTMs related to TMPRSS3.

Cleavage
Glycosylation
Methylation

Bioinformatics Tool for TMPRSS3

Discover related pathways, diseases and genes to TMPRSS3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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