TLE4 Products

TLE4 Antibody
TLE4 Antibody
Species: Hu, Mu, Rt, Bv, Ch, Xp
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
TLE4 Antibody
TLE4 Antibody
Species: Hu
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
TLE4 Antibody
TLE4 Antibody
Species: Hu
Applications: WB, ICC/IF
Host: Mouse Polyclonal
TLE4 293T Cell Transient Over ...
TLE4 293T Cell Transient Overexpre...
Species: Hu
Applications: WB
Recombinant Human TLE4 GST (N ...
Recombinant Human TLE4 GST (N-Term...
Species: Hu
Applications: WB, ELISA, PA, PAGE, AP
TLE4 Recombinant Protein Anti ...
TLE4 Recombinant Protein Antigen
Species: Hu
Applications: AC


The Notch signaling pathway controls cellular interactions important for the specification of a variety of fates in both invertebrates and vertebrates. Key players in the Notch pathway are the TLE genes (for transducin-like enhancer of split, also designated ESG for enhancer of split groucho), which are human homologs of the Drosophila groucho gene. Groucho is a transcriptional repressor that plays a key role in neurogenesis, segmentation and sex determination. TLEs associate with chromatin in live cells and specifically with Histone H3, but not with other core histones. Expression of the TLE genes, TLE1, TLE2, TLE3 and TLE4, correlate with immature epithelial cells that are progressing toward a terminally differentiated state, suggesting a role during epithelial differentiation. TLE1, TLE2 and TLE3 have elevated expression in cervial squamous metaplasias and carcinomas, while TLE4 is most highly expressed in the brain, particularly in the caudate nucleus. TLE1 and TLE4 contain SP and WD40 domains, through which TLE1 binds AML1 to inhibit AML1-induced transactivation of the CSF1 receptor. In early stages of cell differentiation, TLE1 is up-regulated, and TLE2 and TLE4 are down-regulated. In later stages, TLE2 and TLE4 are up-regulated, and expression of TLE1 decreases. TLE1 and TLE2 genes map in a tandem array at chromosomal location 19p13.3. The genetic loci for TLE3 and TLE4 are chromosomes 15q22 and 9, respectively.


Entrez Human
Uniprot Human
Product By Gene ID 7091
Alternate Names
  • KIAA1261
  • BCE1
  • transducin-like enhancer protein 4
  • BCE-1
  • Protein BCE-1
  • homolog of Drosophila E(sp1)
  • E(spI)
  • ESG4
  • transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)

Research Areas for TLE4

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Signal Transduction

PTMs for TLE4

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Bioinformatics Tool for TLE4

Discover related pathways, diseases and genes to TLE4. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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