TLE4 Products

Antibodies
TLE4 Antibody
TLE4 Antibody
NBP2-15140
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
TLE4 Antibody
TLE4 Antibody
NBP2-55862
Species: Hu, Mu, Rt
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
TLE4 Antibody
TLE4 Antibody
H00007091-B01P
Species: Hu
Applications: WB, ICC/IF
Host: Mouse Polyclonal
Lysates
TLE4 Overexpression Lysate (D ...
TLE4 Overexpression Lysate (Denatu...
H00007091-T01
Species: Hu
Applications: WB
Proteins
TLE4 Recombinant Protein Anti ...
TLE4 Recombinant Protein Antigen
NBP2-55862PEP
Species: Hu
Applications: B/N, Ctrl
Recombinant Human TLE4 Protei ...
Recombinant Human TLE4 Protein
H00007091-P01
Species: Hu
Applications: WB, ELISA, PA

Description

The Notch signaling pathway controls cellular interactions important for the specification of a variety of fates in both invertebrates and vertebrates. Key players in the Notch pathway are the TLE genes (for transducin-like enhancer of split, also designated ESG for enhancer of split groucho), which are human homologs of the Drosophila groucho gene. Groucho is a transcriptional repressor that plays a key role in neurogenesis, segmentation and sex determination. TLEs associate with chromatin in live cells and specifically with Histone H3, but not with other core histones. Expression of the TLE genes, TLE1, TLE2, TLE3 and TLE4, correlate with immature epithelial cells that are progressing toward a terminally differentiated state, suggesting a role during epithelial differentiation. TLE1, TLE2 and TLE3 have elevated expression in cervial squamous metaplasias and carcinomas, while TLE4 is most highly expressed in the brain, particularly in the caudate nucleus. TLE1 and TLE4 contain SP and WD40 domains, through which TLE1 binds AML1 to inhibit AML1-induced transactivation of the CSF1 receptor. In early stages of cell differentiation, TLE1 is up-regulated, and TLE2 and TLE4 are down-regulated. In later stages, TLE2 and TLE4 are up-regulated, and expression of TLE1 decreases. TLE1 and TLE2 genes map in a tandem array at chromosomal location 19p13.3. The genetic loci for TLE3 and TLE4 are chromosomes 15q22 and 9, respectively.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Product By Gene ID 7091
Alternate Names
  • KIAA1261
  • BCE1
  • transducin-like enhancer protein 4
  • BCE-1
  • Protein BCE-1
  • homolog of Drosophila E(sp1)
  • E(spI)
  • ESG4
  • transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)

Research Areas for TLE4

Find related products by research area and learn more about each of the different research areas below.

Signal Transduction

PTMs for TLE4

Learn more about PTMs related to TLE4.

Phosphorylation
Acetylation
Methylation

Bioinformatics Tool for TLE4

Discover related pathways, diseases and genes to TLE4. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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