Hu, Mu, RtApplications:
WB, IHC, IHC-PHost:
Applications: WB, ELISA
Host: Mouse Monoclonal
Applications: WB, RNAi, RNAi SP
Applications: RNAi, RNAi SP
Thymidine kinase (TK) belongs to a group of enzymes such as dihydrofolate reductase, thymidylate synthase, and DNA polymerase that are involved in DNA synthesis and precursor production. Two forms have been identified in animal cells, one in cytosol and one in mitochondria. Activity of the cytosolic enzyme is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very low in resting cells due to multiple regulatory mechanisms that ensure expression of these enzymes exclusively in replicating cells. TK is responsible for catalyzing the phosphorylation of thymidine, which functions as a part of the pyrimidine salvage pathway involved in DNA synthesis. The activities of enzymes such as TK are essential for the activation of several chemotherapeutically important nucleoside analogues that are administered as prodrugs.
|Product By Gene ID
- thymidine kinase-1
- thymidine kinase, cytosolic
- thymidine kinase 1 soluble isoform
- EC 184.108.40.206
- thymidine kinase 1, soluble
Bioinformatics Tool for Thymidine Kinase 1
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