TGF-beta RI/ALK-5 Products

Description

Three members of the TGF beta family, TGF beta 1, TGF beta 2 and TGF beta 3, are known in mammals. TGF betas mediate their activity by high affinity binding to the type 2 receptor, which requires both its kinase activity and association with members of a series of related type 1 receptors called activin receptor like kinase (ALK) 1 to 6. Of these, only ALK5 has been shown to represent a functional TGF beta type 1 receptor, but only ALK2 and ALK4 bind activin with high affinity. TGF beta R3 binds TGF beta and retains TGF beta for presentation to the signaling receptors.

Bioinformatics

Entrez	7046 Human
Uniprot	P36897
Product By Gene ID	7046
Alternate Names	AAT5 activin A receptor type II-like kinase, 53kD activin A receptor type II-like kinase, 53kDa Activin receptor-like kinase 5 ACVRLK4 ALK-5 ALK-5ALK5 EC 2.7.11 EC 2.7.11.30 LDS1A LDS2A Serine/threonine-protein kinase receptor R4 SKR4 tbetaR-I TGFB1R1 TGF-beta receptor type I TGF-beta receptor type-1 TGF-beta RI TGF-beta type I receptor TGFbetaRI TGFBR1 TGF-bRI TGFR-1 transforming growth factor beta receptor I transforming growth factor, beta receptor 1 transforming growth factor, beta receptor I (activin A receptor type II-likekinase, 53kD) Transforming growth factor-beta receptor type I

Research Areas for TGF-beta RI/ALK-5

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Protein Kinase