Species: Hu, Mu, Rt, Bv, Ca, Pm, Pm, Pm-Or, Rb
Applications: WB, IHC, IP
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, ELISA, IHC
Host: Mouse Monoclonal
Species: Hu, Mu
Applications: IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Description
Neurotensin (NT) initiates an intracellular response by interacting with the G protein-coupled receptors NTR1 (NTS1 receptor, high affinity NTR) and NTR2 (NTS2 receptor, levocabastine-sensitive neurotensin receptor), and the type I receptor NTR3 (NTS3 receptor, sortilin-1, Gp95). NT has a wide distribution in regions of the brain and in peripheral tissues where NT receptors can contribute to hypotension, hyperglycemia, hypothermia, antinociception and regulation of intestinal motility and secretion. HL-60 cells express NTR1, which can couple to Gq, Gi/o, or Gs. Alternative splicing of rat NTR2 can generate a 5-transmembrane domain variant isoform that is co-expressed with the full-length NTR2 throughout the brain and spinal cord. NTR3 activation in the murine microglial cell line N11 induces MIP-2, MCP-1, IL-1beta and TNFalpha in an ERK1/2 and Akt kinase-dependent manner.
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
Human
|
| Product By Gene ID |
24144 |
| Alternate Names |
- bK445C9.6
- DKFZP434B194
- FLJ22086
- hNtr1
- NTR1
- Septin and tuftelin-interacting protein 1
- STIP
- STIP-1
- TIP39Spp382
- tuftelin interacting protein 11
- tuftelin-interacting protein 11
|
