Species: Hu
Applications: WB
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Description
TAS2R16 encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily. These family members are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. FUNCTION: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in a subset of gustducin-positive taste receptor cells of the tongue. POLYMORPHISM: The Lys-172 polymorphism in TAS2R16 is associated with genetic susceptibility to alcoholism [MIM:103780]. MISCELLANEOUS: Several bitter taste receptors are expressed in a single taste receptor cell. MISCELLANEOUS: Confers bitter perception of salicin to non-taster mice. Useful Links; The Human Olfactory Data Exploratorium: HORDE; Olfactory Receptor Data Base: ORDB; Transmembrane Analysis: TM analysis
Bioinformatics
| Entrez |
Human
Rat
|
| Uniprot |
Human
Human
Rat
|
| Product By Gene ID |
50833 |
| Alternate Names |
- T2R16candidate taste receptor T2R16
- taste receptor type 2 member 16
- taste receptor, type 2, member 16
|
Research Areas for TAS2R16
Find related products by research area and learn more about each of the different research areas below.
GPCR
