TAF6 Products

Description

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Four isoforms have been identified but complete transcripts have been determined for only three isoforms. One of the isoforms has been shown to preclude binding of one of the other TFIID subunits, thereby reducing transcription and initiating signals that trigger apoptosis.

Bioinformatics

Entrez	6878 Human
Uniprot	NP_005632 Human NP_005632.1 Human
Product By Gene ID	6878
Alternate Names	DKFZp781E21155 MGC:8964 RNA polymerase II, E, 70/85kD TAF(II)70 TAF(II)80 TAF2ERNA polymerase II TBP-associated factor subunit E TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa TAFII70TAFII-80 TAFII80TAFII-70 TAFII85 Transcription initiation factor TFIID 70 kDa subunit Transcription initiation factor TFIID 80 kDa subunit transcription initiation factor TFIID subunit 6