SYT17 Products

Description

The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin participates in triggering neurotransmitter release at the synapse. The first C2 domain mediates Ca(2+)-dependent phospholipid binding. The second C2 domain mediates interaction with Stonin 2. Synaptotagmin may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.

Bioinformatics

Entrez	110058 Mouse 192189 Rat 51760 Human
Uniprot	NM_016524 Human Q62807 Rat Q920M7 Mouse Q9BSW7 Human
Product By Gene ID	51760
Alternate Names	B/K protein synaptotagmin XVIIProtein B/K synaptotagmin-17 SytXVII sytXVII