SYT17 Products

Description

The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin participates in triggering neurotransmitter release at the synapse. The first C2 domain mediates Ca(2+)-dependent phospholipid binding. The second C2 domain mediates interaction with Stonin 2. Synaptotagmin may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.

Bioinformatics

Entrez	51760 Human 110058 Mouse 192189 Rat
Uniprot	NM_016524 Human Q9BSW7 Human Q920M7 Mouse Q62807 Rat
Product By Gene ID	51760
Alternate Names	SytXVII sytXVII synaptotagmin-17 B/K protein synaptotagmin XVIIProtein B/K

Diseases related to SYT17

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Pituitary Diseases

PTMs for SYT17

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Phosphorylation

Bioinformatics Tool for SYT17

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