SYNE1 Products

Antibodies
Proteins
Recombinant Human SYNE1 GST ( ...
Recombinant Human SYNE1 GST (N-Ter...
H00023345-Q01
Species: Hu
Applications: WB, ELISA, PA, AP
SYNE1 Recombinant Protein Ant ...
SYNE1 Recombinant Protein Antigen
NBP1-89349PEP
Species: Hu
Applications: AC

Description

There are two genes encoding members of a new family of type II integral membrane proteins. Both are ubiquitously expressed, and tissue-specific alternative mRNA initiation and splicing generate at least two major isoforms of each protein, with the smaller isoforms being truncated at the N-terminus.These proteins are called Nesprin l and 2 for nuclear envelope spectrin repeat, as they are characterized by the presence of multiple, clustered spectrin repeats, bipartite nuclear localization sequences and a conserved C-terminal, single transmembrane domain. Transient transfection of EGFP-fusion expression constructs demonstrated their localization to the nuclear membrane with a novel C-terminal, TM domain-containing sequence essential for perinuclear localization. Nesprin l is developmentally regulated in both smooth and skeletal muscle and is relocalized from the nuclear envelope to the nucleus and cytoplasm during C2Cl2 myoblast differentiation. Nesprins may function as "dystrophins of the nucleus" to maintain nuclear organization and structural integrity. There are two genes encoding members of a new family of type II integral membrane proteins. Both are ubiquitously expressed, and tissue-specific alternative mRNA initiation and splicing generate at least two major isoforms of each protein, with the smaller isoforms being truncated at the N-terminus. These proteins are called Nesprin l and 2 for nuclear envelope spectrin repeat, as they are characterized by the presence of multiple, clustered spectrin repeats, bipartite nuclear localization sequences and a conserved C-terminal, single transmembrane domain. Transient transfection of EGFP-fusion expression constructs demonstrated their localization to the nuclear membrane with a novel C-terminal, TM-domain-containing sequence essential for perinuclear localization. Nesprin l is developmentally regulated in both smooth and skeletal muscle and is relocalized from the nuclear envelope to the nucleus and cytoplasm during C2Cl2 myoblast differentiation. Nesprins may function as "dystrophins of the nucleus" to maintain nuclear organization and structural integrity.

Bioinformatics

Entrez Human
Uniprot Human
Product By Gene ID 23345
Alternate Names
  • EC 4.3.1.3
  • EDMD4
  • EC 4.2.1.49
  • C6orf98
  • Syne-1
  • Synaptic nuclear envelope protein 1
  • Myne-1
  • Nuclear envelope spectrin repeat protein 1
  • Enaptin
  • Myocyte nuclear envelope protein 1
  • synaptic nuclei expressed gene 1
  • nesprin-1
  • nesprin 1
  • enaptin
  • dJ45H2.2
  • CPG2
  • ARCA1
  • KIAA17568B
  • KIAA1262FLJ41140
  • SCAR8FLJ30878
  • MYNE1DKFZp781J13156
  • KIAA0796chromosome 6 open reading frame 98
  • SYNE-1B
  • spectrin repeat containing, nuclear envelope 1

PTMs for SYNE1

Learn more about PTMs related to SYNE1.

Methylation

Bioinformatics Tool for SYNE1

Discover related pathways, diseases and genes to SYNE1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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