Swi6 Products

Antibodies
Swi6 Antibody
Swi6 Antibody
NB600-932
Species: Ye
Applications: WB, ELISA
Host: Rabbit Polyclonal

Description

The chromatin structure of Fission yeast centromeres is regulated epigenetically. In the central core domain, the histone H3 variant Cnp1(CENP-A) plays a key role. In the flanking heterochromatin domain, histones are kept underacetylated by the histone deacetylases (HDACs) Clr3, Clr6 and Sir2, and methylated by Clr4 methyltransferase (HMTase) to create a specific binding site for the Swi6 protein. Swi6 then directly mediates cohesin binding to the centromeric heterochromatin. Recognizes and binds histone H3 tails methylated at Lys-9, leading to epigenetic repression. Involved in the repression of the silent mating-type loci MAT2 and MAT3. May compact MAT2/3 into a heterochromatin-like conformation which represses the transcription of these silent cassettes. Swi6 interacts with histone H3 methylated at Lys-9 and with the cohesin subunit psc3. Swi6 associates with Swi4 to activate HO and many other late G1-specific transcripts in budding yeast. In contrast, histone H3 methylated at Lys9 and its interacting protein Swi6/HP1, which define heterochromatin, coated extended domains associated with a variety of repeat elements and small islands corresponding to meiotic genes. Contains two chromo domains.

Bioinformatics

Product By Gene ID 850879
Alternate Names
  • Chromatin-associated swi6 protein; Regulatory protein SWI6

Research Areas for Swi6

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Chromatin Research

Bioinformatics Tool for Swi6

Discover related pathways, diseases and genes to Swi6. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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