SUG1 Products

Description

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Bioinformatics

Product By Gene ID	5705
Alternate Names	MSUG1 protein p45 p45/SUG26S protease regulatory subunit 8 proteasome (prosome, macropain) 26S subunit, ATPase, 5 proteasome 26S ATPase subunit 5 Proteasome 26S subunit ATPase 5 Proteasome subunit p45 S8 SUG-1 SUG126S proteasome AAA-ATPase subunit RPT6 Tat-binding protein homolog 10 TBP10 thyroid receptor interactor 1 TRIP1Thyroid hormone receptor-interacting protein 1