SPOP Products

Description

SPOP encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq]

Bioinformatics

Entrez	8405 Human
Uniprot	NM_001007229 Human NM_003563 Human NP_001007227 Human NP_001007227.1 Human NP_001007229 Human NP_001007231 Human O43791 Human
Product By Gene ID	8405
Alternate Names	HIB homolog 1 Roadkill homolog 1 speckle-type POZ protein TEF2