SPOP Products

Description

SPOP encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq]

Bioinformatics

Entrez	8405 Human
Uniprot	NM_001007229 Human NM_003563 Human NP_001007227 Human NP_001007227.1 Human NP_001007229 Human NP_001007231 Human O43791 Human
Product By Gene ID	8405
Alternate Names	HIB homolog 1 Roadkill homolog 1 speckle-type POZ protein TEF2

Diseases related to SPOP

Discover more about diseases related to SPOP.

Malignant Neoplasms
Neoplasms
Cell Transformation, Neoplastic
Diabetes Mellitus
Insulinoma
Scleroderma
Mammary Neoplasms
Malignant Neoplasm Of Prostate
Prostatic Neoplasms
Leukoencephalopathy, Progressive Multifocal
Neoplasm Metastasis
Malnutrition
Malignant Neoplasm Of Kidney
Malignant Neoplasm Of Breast
Glioma
Endometrial Polyp
Kidney Neoplasm
Carcinoma
Mulibrey Nanism

Pathways for SPOP

View related products by pathway and learn more about each of the pathways below.

Localization
Glucose Homeostasis
Transport
Histone Deacetylation
Pancreas Development
Induction Of Apoptosis
Fertilization
Dna Methylation
Proteolysis
Methylation
Cell Cycle
Sperm Capacitation
Cell Differentiation
Cullin Deneddylation
Segmentation
Intraflagellar Transport
Eye Development
Pathogenesis

PTMs for SPOP

Learn more about PTMs related to SPOP.

Ubiquitination
Phosphorylation
Cleavage
Deacetylation
Methylation

Bioinformatics Tool for SPOP

Discover related pathways, diseases and genes to SPOP. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.