Sodium Potassium ATPase Alpha 2 Products

Description

The ubiquitously expressed sodium/potassium-ATPase exists as a oligomeric plasma membrane complex that couples the hydrolysis of one molecule of ATP to the importation of three Na+ ions and two K+ ions against their respective electrochemical gradients. As a member of the P-type family of ion motifs, sodium/potassium-ATPase plays a critical role in maintaining cellular volume, resting membrane potential and Na+-coupled solute transport. Multiple isoforms of three subunits, alpha, beta and gamma, comprise to form the sodium/potassium-ATPase oligomer. The 113 kDa alpha subunit contains the binding sites for ATP and the cations. With a molecular weight between 40 and 60 kDa, the glycosylated beta subunit ensures correct folding and membrane insertion of the alpha subunits. The small 6 kDa gamma subunit co-localizes with the alpha subunit in nephron segments, where it increases the affinity of sodium/potassium-ATPase for ATP. The beta subunit, but not the gamma subunit, is essential for normal activity of sodium/potassium-ATPase.

Bioinformatics

Product By Gene ID

477

Alternate Names

alpha-A(+) catalytic polypeptide ATP1A2 ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide ATPase, Na+/K+ transporting, alpha 2 polypeptide EC 3.6.3 EC 3.6.3.9 KIAA0778 MGC59864 MHP2 migraine, hemiplegic 2 Na(+)/K(+) ATPase alpha-2 subunit Na+/K+ ATPase, alpha-B polypeptide Sodium Potassium ATPase Alpha 2 Sodium pump subunit alpha-2 sodium/potassium-transporting ATPase alpha-2 chain sodium/potassium-transporting ATPase subunit alpha-2 sodium-potassium ATPase

Research Areas for Sodium Potassium ATPase Alpha 2

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