SNAP23 Products

Description

Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene.

Bioinformatics

Entrez	8773 Human
Uniprot	NP_003816.2 Human
Product By Gene ID	8773
Alternate Names	HsT17016 SNAP23 SNAP-23 SNAP23A SNAP23B synaptosomal-associated protein 23 synaptosomal-associated protein, 23kD synaptosomal-associated protein, 23kDa Vesicle-membrane fusion protein SNAP-23

Research Areas for SNAP23

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Protein Phosphatase