SMAD1/5/9 Products


Smad proteins, the mammalian homologs of the Drosophila Mothers against dpp (Mad) have been implicated as downstream effectors of TGFbeta/BMP signaling. Smad1 (also designated Madr1 or JV4-1), Smad5 and mammalian Smad8 (also designated Smad9 or MadH6) are effectors of BMP2 and BMP4 function while Smad2 (also designated Madr2 or JV18-1) and Smad3 are involved in TGFbeta and activin-mediated growth modulation. Smad4 (also designated DPC4) has been shown to mediate all of the above activities through interaction with various Smad family members. Smad6 and Smad7 regulate the response to activin/TGFbeta signaling by interfering with TGFbeta-mediated phosphorylation of other Smad family members.


Entrez Human
Uniprot Human
Product By Gene ID 4086
Alternate Names
  • Smad1
  • Mad-related protein 1
  • transforming growth factor-beta signaling protein 1
  • MAD homolog 1
  • TGF-beta signaling protein 1
  • hSMAD1
  • SMAD, mothers against DPP homolog 1
  • BSP1
  • mothers against decapentaplegic homolog 1
  • BSP-1
  • mothers against decapentaplegic homolog 1
  • Mothers against DPP homolog 1
  • MADH1JV41
  • JV4-1SMAD, mothers against DPP homolog 1 (Drosophila)
  • MADR1MAD, mothers against decapentaplegic homolog 1 (Drosophila)
  • SMAD family member 1SMAD 1

Research Areas for SMAD1/5/9

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Diabetes Research
Stem Cell Signaling Pathway

Bioinformatics Tool for SMAD1/5/9

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