Species: Hu
Applications: WB, ELISA, ICC/IF, IHC, KD
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Applications: WB, Flow, IHC, IP
Host: Rabbit Monoclonal
Species: Hu, Mu, Rt, Po, Pm, Bv, Ca, Pm, Eq, Pm, Ma-Op, RM, Ze
Applications: WB, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Species: Hu
Applications: Bioactivity
Description
SGK1 encodes a serine/threonine protein kinase that is highly similar to the rat serum-and glucocorticoid-induced protein kinase (SGK). This gene was identified in a screen of hepatocellular genes regulated in response to cellular hydration or swelling. Cellular hydration is a catabolic signal, stimulating glycogenolysis and proteolysis, and inhibiting protein and glycogen synthesis. This kinase has been shown to be important in activating certain potassium, sodium, and chloride channels. Expression of this gene in hepatocytes is stimulated by transforming growth factor-beta (TGF-beta) which participates in the pathophysiology of diabetic complications. Since both TGF-beta expression and SGK expression are elevated in diabetic nephropathy, this suggests an involvement of SGK in the development of this condition.
Bioinformatics
| Entrez |
Mouse
Rat
Human
|
| Uniprot |
Human
Human
Human
Human
Human
|
| Product By Gene ID |
6446 |
| Alternate Names |
- EC 2.7.11
- EC 2.7.11.1
- serine/threonine protein kinase SGK
- serine/threonine-protein kinase Sgk1
- serum/glucocorticoid regulated kinase 1
- serum/glucocorticoid regulated kinase
- Serum/glucocorticoid-regulated kinase 1
- SGK
|
Research Areas for SGK1
Find related products by research area and learn more about each of the different research areas below.
ApoptosisDNA Repair
![SDS-PAGE SGK1 [Unconjugated]](http://images.novusbio.com/fullsize2/SGK_3200KS_906.jpg)
