SGK1 Products

Description

SGK1 encodes a serine/threonine protein kinase that is highly similar to the rat serum-and glucocorticoid-induced protein kinase (SGK). This gene was identified in a screen of hepatocellular genes regulated in response to cellular hydration or swelling. Cellular hydration is a catabolic signal, stimulating glycogenolysis and proteolysis, and inhibiting protein and glycogen synthesis. This kinase has been shown to be important in activating certain potassium, sodium, and chloride channels. Expression of this gene in hepatocytes is stimulated by transforming growth factor-beta (TGF-beta) which participates in the pathophysiology of diabetic complications. Since both TGF-beta expression and SGK expression are elevated in diabetic nephropathy, this suggests an involvement of SGK in the development of this condition.

Bioinformatics

Entrez	20393 Mouse 29517 Rat 6446 Human
Uniprot	AAH01263 Human AAH01263.1 Human NM_005627 Human NP_005618 Human O00141 Human
Product By Gene ID	6446
Alternate Names	EC 2.7.11 EC 2.7.11.1 serine/threonine protein kinase SGK serine/threonine-protein kinase Sgk1 serum/glucocorticoid regulated kinase 1 serum/glucocorticoid regulated kinase Serum/glucocorticoid-regulated kinase 1 SGK

Research Areas for SGK1

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Apoptosis
DNA Repair